Table 1.

Comparative cell density analysis of the pars compacta across groups of ovariectomized females and untreated normal males and females of similar ages: serial section densities with SDs

Monkey numberDensity of TH/unit volumeSDNumber of sectionsNewman–Keuls*% intact females
Intact female
 1217511117
 2216819717
 3217914017
 Mean2174150B100%
Male
 4175410316
 5176711416
 6172715516
 Mean1750124C80%
10 d OVX
 7136225117
 8135223017
 9142820617
 Mean1381228D64%
10 d OVX plus 2 d estrogen treatment
 10249422817
 11242920715
 12244016816
 Mean2456201A113%
30 d OVX plus 2 d estrogen treatment
 13129218818
 14136912017
 15137513017
 Mean1344152D62%
  • ANOVA, (group) F = 482; df = 4,10;p < 0.0001; (section) F = 0.45; df = 17,155; p = NS; (monkey) F = 0.59; df = 10,155; p = NS.

  • * Groups with same letter are not different (p < 0.05).

  • The density of TH neurons is shown.

  • ANOVA of TH density showed highly significant differences between the groups but no differences between the sections (F = 0.45; df = 17,155) or monkeys within groups (F = 0.59; df = 10,155) and no significant interactions in a two-factor, repeated measures design. Post hoc tests (Student; Newman–Keuls) showed that all groups were different from each other, except for the 30 d OVX plus 2 d estrogen treatment and the 10 d OVX without estrogen groups. Groups with the same letter are not different (p < 0.05).