Table 1.

Effects of SL 327 on dopamine-induced cAMP production on striatal mouse slices

Dopamine (m)SL 327 (μm)% increase
10−40124  ± 9
 01012  ± 8
 01007  ± 6
10−40.3129  ± 21
10−43126  ± 3
10−410167  ± 42
10−430163  ± 42
10−4100143  ± 22
10−4300140  ± 30
  • Adenylyl cyclase activity stimulated by dopamine was measured in presence of increasing doses of SL327 (0.3–300 μm). Results were calculated in picomoles of cAMP formed per minute per milligram of protein and expressed in percentage of increase when compared to the basal adenylyl cyclase activity (n = 3 individual experiments run in triplicate). Note the lack of effects of SL327 on both the basal and dopamine-induced cAMP levels.