Membrane properties and postsynaptic currents in the pyramidal neurons of cortex
| Control pyramidal neuron | DC pyramidal neuron | ||
|---|---|---|---|
| Layer II/III | Layer V | ||
| Membrane properties | |||
| Vm (mV) | −67.2 ± 2.8 | −69.6 ± 3.1 | −68.5 ± 2.6 |
| Ra(mΩ) | 16.3 ± 1.2 | 15.9 ± 1.5 | 14.7 ± 1.8 |
| Rm (mΩ) | 203 ± 15 | 222 ± 18 | 211 ± 20 |
| n | 14 | 10 | 22 |
| sIPSCs | |||
| Amp (pA) | 33.88 ± 1.39 | 34.51 ± 1.2 | 22.4 ± 1.77* |
| Fre (Hz) | 13.19 ± 0.88 | 13.73 ± 0.94 | 4.07 ± 0.46* |
| RT (msec) | 1.85 ± 0.17 | 1.63 ± 0.18 | 1.88 ± 0.11 |
| τ (msec) | 10.64 ± 0.81 | 11.36 ± 0.98 | 11.4 ± 0.82 |
| n | 11 | 9 | 19 |
| sEPSCs | |||
| Amp (pA) | 22.94 ± 1.02 | 21.78 ± 1.02 | 28.8 ± 0.92* |
| Fre (Hz) | 2.84 ± 0.29 | 3.11 ± 0.28 | 5.49 ± 0.47* |
| RT (msec) | 1.91 ± 0.11 | 1.77 ± 0.16 | 2.02 ± 0.16 |
| τ (msec) | 8.00 ± 0.43 | 7.82 ± 0.68 | 7.38 ± 0.7 |
| n | 14 | 11 | 28 |
DC, Dysplastic cortex; Vm, resting membrane potential; Ra, access resistance; Rm, membrane resistance; Amp, amplitude; Fre, frequency; RT, 10–90% rise time; τ, decay time constant.
↵* p < 0.001.