Table 1.

Analysis of gene expression profiles in the hippocampus of inducible ΔFosB-expressing transgenic mice

GeneGenBank accession number% Regulation
FosBx14897467%
ATP-dependent DNA helicase IIx66323135%
Somatostatin receptor 2m181832102%
Caspase-11u5946392%
PCNAx5306887%
Relaxinz2708883%
Translinx8146483%
DNA ligase IIIu6605879%
MLH1 DNA mismatch repair proteinu5988377%
Ung1x9901868%
Oxidative stress-induced proteinu4093067%
Glutathione S-transferase Pi 1d3068767%
MHR23Bx9241167%
Cdk5d2967861%
DNA excision repair protein ERCC5d1630661%
Ets-related Sap1Az3688558%
IL-10 receptorl1212055%
Baxl2247251%
RIP cell death proteinu2599551%
Ubiquitin-conjugated enzymex9685951%
PI3 kinase p110u03279−76%
PI3 kinase p85m60651−76%
Tie 2 proto-oncogenes67051−77%
Cyclin Cu62638−77%
Myeloblastin, serine proteaseu43525−77%
IL-6 receptor gp130m83336−78%
5-HT 1bz11597−79%
Leukocyte adhesion LFA-1x14951−79%
GABA-A transporter 3l04663−79%
PAX-8x57487−80%
Desmocolin 2l33779−81%
5-HT 2s49542−82%
Interferon inducible protein 1u19119−84%
Kruppel-like factoru25096−86%
  • PhosphorImager analysis of gene expression profiles of the hippocampus of mice expressing ΔFosB or not expressing ΔFosB revealed 34 genes that were upregulated or downregulated by ΔFosB by >50%. The results are representative of three independent determinations.

  • IL, Interleukin; LFA, leukocyte function-associated antigen; PI3, phosphatidylinositol 3; PCNA, proliferating cell nuclear antigen; MHR23B, Rad23 UV excision repair protein homologue; ERCC5, DNA excision repair protein; PAX, paired box protein; MLH1, MLH1 DNA mismatch repair protein.