Table 1.

Comparison of firing properties between wild-type and mutant FS cells in the neocortex

Layer V–VILayer I–IV
pWild-type n = 20Knock-out n = 20pWild-type n = 10Knock-out n = 10
Resting Vm(mV)---−64.45  ± 0.54−63.60  ± 0.57---−64.22  ± 0.75−64.10  ± 0.60
Rinput(MΩ)---133.37  ± 6.19142.42 ± 8.61---153.50  ± 17.92116.10  ± 8.60
Threshold (mV)---−38.35  ± 0.59−38.81  ± 1.02---−37.04  ± 1.13−38.27  ± 0.67
Maximum rising slope (mV/msec)---155.54  ± 2.90149.65  ± 8.04---151.65  ± 6.33165.36  ± 7.53
Maximum falling slope (mV/msec)***−84.07  ± 1.84−61.11  ± 5.07---−79.37  ± 5.75−86.08  ± 4.75
Spike width at half amplitude (msec)***0.74  ± 0.0180.94  ± 0.038---0.78  ± 0.0310.75  ± 0.036
AHP Amp (mV)**16.14  ± 0.6812.34  ± 0.79---17.64  ± 1.0615.86  ± 0.69
AHP deceleration (mV/msec2)***133.88  ± 5.7184.11  ± 7.34---130.00  ± 8.63135.96  ± 12.49
SS firing rate (Hz)*152.11  ± 7.04116.63  ± 10.21---134.47  ± 7.52155.21  ± 13.35
SS firing rate/initial frequency**0.85  ± 0.0180.71  ± 0.031---0.80  ± 0.0230.83  ± 0.035
  • FS cells are organized by the cortical layer in which they were found. Spike width, AHP, and slope measurements are from single action potentials. Vm, Membrane potential;Rinput, input resistance of the cell; Amp, amplitude; SS, steady state. p values determined by Student's t test. *p < 0.01; **p < 0.001; ***p < 0.0001; dashed lines indicate non- significance (p > 0.05).