Table 1.

Spinal cord cells containing activated caspase-3 and β-actin fragment

mSOD1NontransgenicmSOD1/Bcl-2
Beginning of symptomsEnd-stageAge-matched1-aAge-matched1-aEnd-stage
MN65  ± 3*32  ± 21-16074  ± 261  ± 2*34  ± 21-160
CM1 × 103.3  ± 0.62.7  ± 0.601.2  ± 0.5†3.1  ± 0.9
Fractin × 103.7  ± 0.62.8  ± 0.801.5  ± 0.4†2.7  ± 0.5

  • ↵F1-a Killed simultaneously with transgenic mSOD1 end-stage littermates. Cells were counted in the lumbar segment of the spinal cord. Data represent mean per section ± SEM for three to five mice per group. MN, Motor neuron.

  • ↵* p < 0.05 and

  • ↵F1-160 p< 0.01 lower than wild-type mice;

  • ↵† p < 0.05 lower than beginning of symptoms and end-stage transgenicmSOD1, Newman–Keuls post hoc test.