Astrocyte-induced neuronal responses were unaffected by glutamate transporter inhibitors
| Control | t-PDC | Control | β-HA | Control | DHK | Sodium | Lithium | |
|---|---|---|---|---|---|---|---|---|
| Astrocytes that evoked neuronal responses (%) | 61.0 ± 3.9 | 66.8 ± 8.6 | 54.8 ± 2.4 | 63.5 ± 5.4 | 75.4 ± 4.0 | 76.4 ± 3.6 | 74.5 ± 5.5 | 76.1 ± 3.9 |
| (n = 3) | (n= 3) | (n = 3) | (n = 3) | (n = 3) | (n = 3) | (n = 3) | (n = 3) | |
| SIC amplitude (pA) | 39.3 ± 10.0 | 42.9 ± 7.0 | 30.6 ± 7.7 | 28.5 ± 3.5 | 37.1 ± 5.3 | 43.9 ± 9.1 | 159.7 ± 25.2 | 193.5 ± 29.0 |
| (n = 15) | (n = 17) | (n = 21) | (n = 19) | (n = 23) | (n = 24) | (n = 23) | (n = 23) |
Control solutions include 2 mm Mg2+, except for extracellular sodium and lithium in which extracellular Mg2+ was omitted. No significant differences were found between control and test conditions (Student's ttest).