Mean ± SEM number of Fos-positive nuclei in all regions sampled
| Brain region | Environment only | Environment and priming injections | |||||
|---|---|---|---|---|---|---|---|
| Controls (n = 5) | Extinction (n = 7) | No extinction (n = 5) | No extinction– no lever (n = 6) | Controls (n = 6) | Extinction (n = 6) | No extinction (n = 6) | |
| Nucleus accumbens - core | 20.60 ± 4.31 | 18.11 ± 4.22 | 33.25 ± 2.99 | 28.96 ± 5.70 | 21.14 ± 5.46 | 30.70 ± 8.76 | 42.39 ± 6.21 |
| - shell | 19.36 ± 5.49 | 20.28 ± 4.68 | 27.13 ± 5.78 | 35.30 ± 7.85 | 13.27 ± 3.22 | 19.24 ± 4.83 | 35.53 ± 7.49 |
| Ventral pallidum | 9.42 ± 2.12 | 13.99 ± 4.71 | 13.85 ± 4.37 | 7.30 ± 1.84 | 8.29 ± 3.18 | 17.32 ± 1.95 | 18.71 ± 2.56 |
| Ventral tegmental area | 3.56 ± 1.59 | 5.24 ± 1.50 | 12.62 ± 6.12 | 10.02 ± 2.66 | 19.32 ± 6.97 | 13.66 ± 1.13 | 17.70 ± 4.22 |
| Dorsal caudate putamen | 9.68 ± 4.76 | 2.71 ± 0.96 | 16.59 ± 5.97 | 14.18 ± 4.15 | 17.53 ± 7.07 | 25.96 ± 4.89 | 31.52 ± 5.84 |
| Substantia nigra - compacta | 5.76 ± 2.00 | 8.08 ± 2.81 | 8.54 ± 2.46 | 7.63 ± 1.86 | 8.89 ± 2.35 | 9.29 ± 2.04 | 13.42 ± 3.10 |
| - reticulata | 2.47 ± 0.84 | 7.03 ± 2.72 | 8.28 ± 1.95 | 6.26 ± 1.66 | 13.18 ± 2.90 | 23.11 ± 5.00 | 27.61 ± 3.30 |
| Cortex - motor | 23.71 ± 6.80 | 15.08 ± 4.98 | 32.44 ± 8.03 | 30.51 ± 5.04 | 23.14 ± 5.03 | 29.13 ± 5.48 | 38.58 ± 5.46 |
| - anterior cingulate | 20.42 ± 4.31 | 19.25 ± 6.28 | 40.49 ± 8.32 | 38.68 ± 9.72 | 20.34 ± 6.23 | 41.89 ± 5.99 | 41.12 ± 8.25 |
| - entorhinal | 10.33 ± 1.82 | 12.28 ± 2.32 | 14.24 ± 1.45 | 17.31 ± 1.23 | 15.63 ± 3.29 | 20.54 ± 3.02 | 18.36 ± 2.01 |
| Amygdala - basolateral | 4.92 ± 1.76 | 5.67 ± 1.34 | 12.99 ± 5.03 | 11.02 ± 1.38 | 8.41 ± 1.60 | 10.29 ± 1.90 | 15.43 ± 1.90 |
| - medial | 12.28 ± 3.43 | 10.58 ± 2.26 | 16.06 ± 6.15 | 20.16 ± 4.42 | 10.83 ± 2.22 | 9.23 ± 2.29 | 20.06 ± 5.16 |
| - central | 9.12 ± 2.15 | 13.67 ± 3.42 | 11.21 ± 3.19 | 11.52 ± 2.26 | 39.86 ± 9.77 | 40.13 ± 8.84 | 44.91 ± 8.75 |
| - lateral | 0.55 ± 0.23 | 0.85 ± 0.23 | 1.17 ± 0.38 | 1.57 ± 0.31 | 2.99 ± 1.25 | 3.27 ± 0.55 | 5.03 ± 1.53 |
| - cortical | 4.22 ± 2.25 | 1.36 ± 0.28 | 4.58 ± 0.96 | 8.06 ± 3.40 | 2.55 ± 0.94 | 2.65 ± 0.67 | 4.00 ± 1.49 |
| Hippocampal - CA1 region | 8.98 ± 1.87 | 9.73 ± 1.88 | 11.23 ± 0.61 | 14.79 ± 2.56 | 7.84 ± 1.50 | 7.93 ± 1.39 | 14.43 ± 2.90 |
| - CA3 region | 3.60 ± 1.45 | 5.47 ± 2.65 | 5.16 ± 0.90 | 4.18 ± 0.97 | 3.69 ± 1.00 | 3.51 ± 0.91 | 4.40 ± 0.50 |
| - dentate gyrus | 5.10 ± 1.49 | 4.95 ± 1.15 | 6.34 ± 0.37 | 7.36 ± 1.38 | 3.37 ± 0.51 | 3.34 ± 0.78 | 6.08 ± 0.52 |
| - v. subiculum | 21.95 ± 4.26 | 17.48 ± 2.35 | 26.81 ± 3.64 | 31.07 ± 3.95 | 17.11 ± 1.74 | 17.07 ± 3.35 | 27.37 ± 7.26 |
| Lateral septal area | 17.64 ± 5.95 | 13.17 ± 5.11 | 13.87 ± 4.71 | 13.83 ± 3.62 | 7.35 ± 1.98 | 6.92 ± 2.00 | 16.44 ± 3.44 |
| Lateral hypothalamus | 13.45 ± 1.83 | 12.21 ± 1.67 | 15.81 ± 6.49 | 16.56 ± 3.06 | 17.62 ± 2.59 | 16.35 ± 1.95 | 21.11 ± 3.67 |
| Arcuate nucleus | 17.46 ± 3.57 | 21.12 ± 2.80 | 24.87 ± 4.28 | 36.13 ± 4.46 | 23.79 ± 3.33 | 38.33 ± 6.20 | 35.79 ± 9.07 |
| Central gray area | 10.04 ± 2.50 | 10.42 ± 1.14 | 17.05 ± 3.45 | 13.57 ± 3.02 | 18.95 ± 2.02 | 16.37 ± 1.39 | 17.24 ± 1.43 |