Table 2.

Behavioral effect of intra-mPFC SKF 38393 (0.06 μg/side) or SCH 23390 (0.3 μg/side) on a five-choice serial reaction time task

% OmissionsLatency correct (sec)
Low baselineControl vehicle12.9  ± 2.80.63  ± 0.04
(n = 9)SKF 38393 (0.06 μg/side)7.7  ± 1.8*0.60  ± 0.03
High baselineControl vehicle11.4  ± 1.60.58  ± 0.03
(n = 14)SKF 38393 (0.06 μg/side)12.1  ± 2.10.57  ± 0.03
Low baselineControl vehicle10.9  ± 1.90.61  ± 0.04
(n = 13)SCH 23390 (0.3 μg/side)12.3  ± 2.20.66  ± 0.03
High baselineControl vehicle9.7  ± 1.80.58  ± 0.03
(n = 11)SCH 23390 (0.3 μg/side)10.1  ± 2.30.59  ± 0.03
  • Mean ± SEM values are shown.

  • *Indicates a significant difference compared to control vehicle (p < 0.05).