Table 3.

Antagonism of the effect of intra-mPFC infusion of SKF 38393 (0.06 μg/side) by intra-mPFC SCH 23390 (1 μg/side) on five-choice serial reaction time task

% Correct% OmissionsLatency correct (sec)
Low baselineControl vehicle69.8  ± 1.19.4  ± 2.20.58  ± 0.04
(n = 5)SKF 38393 (0.06 μg/side)79.6  ± 2.7*5.8  ± 2.30.58  ± 0.04
SCH 23390 (1 μg/side)72.4  ± 1.310.8  ± 2.80.66  ± 0.03
SKF 38393 (0.06 μg/side) + SCH23390 (1 μg/side)71.8  ± 1.612.2  ± 3.60.71  ± 0.04
High baseline Control vehicle81.5  ± 1.012.4  ± 2.10.61  ± 0.04
(n = 10)SKF 38393 (0.06 μg/side)80.1  ± 1.912.5  ± 2.70.61  ± 0.04
SCH 23390 (1 μg/side)83.2  ± 1.321.9  ± 3.80.65  ± 0.05
SKF 38393 (0.06 μg/side) + SCH23390 (1 μg/side)78.3  ± 1.918.1  ± 3.20.60  ± 0.03
  • Mean ± SEM values are shown.

  • *Indicates a significant difference compared to control vehicle (p < 0.05).