Table 1.

Time-dependent effects of intraplantar injection of CFA or saline on paw withdrawal latency, paw diameter, and body weight

Intraplantar treatmentPaw withdrawal latency (sec)Paw diameter (mm)Weight (% baseline)
IpsilateralContralateralIpsilateralContralateral
4 hr
 CFA3.7  ± 0.1a,b10.2  ± 0.29.6  ± 0.07a,b6.2  ± 0.0498.4  ± 0.8
 Saline9.7  ± 0.29.7  ± 0.26.2  ± 0.046.1  ± 0.03100.8  ± 1.0
4 d
 CFA4.9  ± 0.1a,b9.8  ± 0.19.5  ± 0.08a,b6.2  ± 0.04104.0  ± 1.2
 Saline9.7  ± 0.19.7  ± 0.16.1  ± 0.046.2  ± 0.04105.9  ± 0.9
2 weeks
 CFA5.7  ± 0.1a,b9.8  ± 0.18.9  ± 0.06a,b6.3  ± 0.03109.6  ± 1.5
 Saline9.7  ± 0.19.8  ± 0.16.3  ± 0.046.3  ± 0.03112.5  ± 1.5
  • Values represent the mean ± SEM of determinations made in 61–99 CFA-treated and 46–71 saline-treated rats.

  • F1-a Indicates a significant difference from the corresponding hindpaw of saline-treated rats, p < 0.01.

  • F1-b Indicates a significant difference from the contralateral hindpaw, p < 0.01.