Table 3.

Specific activities of amino acids in cerebellar granule cells incubated with [1-14C]pyruvate or [2-14C]pyruvate in the presence and absence of 3-nitropropionic acid

AspartateGlutamateAlanine
[1-14C]Pyruvate, Control105  ± 247.7  ± 2.7134  ± 10
[1-14C]Pyruvate, 3-NPA249  ± 36*5.7  ± 2.064.0  ± 20.6*
  • Cerebellar granule cells were incubated for 60 min with [1-14C]pyruvate and 3-nitropropionic acid (3-NPA), an inhibitor of succinate dehydrogenase. Values are dpm/nmol, means ± SEM. *Different from control value; p < 0.05, Student's t test.