Metabolic alterations in Apoe−/−mice
| Characteristic | 6-Month-old | 18-Month-old | ||
|---|---|---|---|---|
| Wild-type | Apoe−/− | Wild-type | Apoe−/− | |
| Body weight (gm) | 33.9 ± 0.8 | 33.2 ± 2.0 | 31.2 ± 1.0 | 41.5 ± 3.7* |
| Stomach2-a | 172.8 ± 20.0 | 229.6 ± 33.2 | 205.5 ± 7.1 | 286.3 ± 44.2* |
| Adipose Tissues2-a | ||||
| Interscapular brown | 33.6 ± 0.3 | 30.7 ± 1.2 | 38.0 ± 3.8 | 24.2 ± 0.4* |
| Mesenteric white | 161.7 ± 15.6 | 108.4 ± 19.1 | 226.1 ± 14.2 | 197.4 ± 19.2 |
| Epididymal white | 141.8 ± 15.6 | 59.3 ± 4.7** | 105.0 ± 10.4 | 74.0 ± 8.3* |
| Leptin (ng/ml) | 6.3 ± 0.9 | 1.7 ± 0.5** | 4.3 ± 0.8 | 2.6 ± 0.6* |
n = 4–8 mice per group.
↵F2-a Values represent mg/10 gm body weight to correct for differences in body weight.
*p < 0.05; **p < 0.01 versus wild-type (Tukey–Kramer test).