Table 1.

Developmental expression pattern of BrdU-positive cells in wild-type and Lis1+/− mice

E11+/+ (n = 5)E11+/− (n = 7)E13+/+ (n = 7)E13+/− (n = 7)E14+/+ (n = 5)E14+/− (n = 6)E15+/+ (n = 10)E15+/− (n = 10)E17+/+ (n = 10)E17+/− (n = 8)
CA1
 Stratum pyramidale9.6  ± 3.522.7  ± 4.2*127.7  ± 13.1114.0  ± 4.3144.4  ± 4.4135.7  ± 11.943.4  ± 1.234.9  ± 3.8*5.6  ± 1.17.5  ± 1.8
 Extra pyramidalea39.2  ± 4.148.4  ± 7.9116.4  ± 10.4115.0  ± 6.1105.2  ± 3.576.0  ± 8.1*19.8  ± 1.218.8  ± 1.420.7  ± 4.419.5  ± 4.8
CA3
 Stratum pyramidale12.6  ± 3.814.4  ± 2.470.3  ± 5.858.0  ± 4.3117.2  ± 5.8123.4  ± 7.938.4  ± 2.229.3  ± 2.3*3.9  ± 0.64.0  ± 0.5
 Extra pyramidale16.8  ± 2.725.4  ± 3.080.3  ± 6.473.0  ± 11.470.2  ± 7.560.0  ± 3.912.8  ± 1.118.4  ± 1.36.1  ± 1.18.9  ± 1.4
Dentate gyrus52.8  ± 15.459.5  ± 3.2122.3  ± 9.7108.0  ± 12.5129.8  ± 3.9124.2  ± 11.239.1  ± 1.633.4  ± 2.576.4  ± 4.871.1  ± 6.4
  • Pregnant dams were injected at E11, 13, 14, 15, and 17, and pups were killed at P30.

  • F1-a Extra pyramidale is defined as the stratum radiatum, stratum oriens-alveus, and in the case of CA1 the stratum lacunosum-moleculare.

  • *Indicates statistical significance compared with age-matched wild-type at the p < 0.05 level (Student's unpairedt test).