Table 1.

Properties of NMDA receptors in NR1gene-targeted mice

NR1genotypesINMDA in pACa2+ reversal potential in mVPCa/PNa
P0P14
+/+267  ± 76 (n = 5)413  ± 90 (n = 8)18.2  ± 0.3 (n = 10)6.3  ± 0.2 (n = 10)
Q/Q243  ± 107 (n = 6)−8.5  ± 1.3 (n = 4)1.4  ± 0.1 (n = 4)
+/Q171  ± 78 (n = 4)418  ± 56 (n = 7)15.8  ± 0.2 (n = 4)5.4  ± 0.04 (n = 4)
+/RND71  ± 33 (n = 4)−3.8  ± 1.6 (n = 6)1.8  ± 0.2 (n = 6)
  • Averaged NMDA receptor-mediated peak currents were recorded at +60 mV holding potential from hippocampal CA1 pyramidal cells of animals at P0 and P14. The Ca2+ to Na+permeability ratios (PCa/PNa) were derived from the shift in Ca2+ reversal potential when switching from high extracellular Na+ to high extracellular Ca2+ solution. Values are given as mean ± SEM. ND, Not determined.