Table 2.

Phenotypes of NR1 gene-targeted mice

NR1genotypesPhenotypes
−/−
Qneo/QneoDeath within 10 hr after birth; respiratory deficits;
Rneo/Rneo  no feeding
Q/Q
−/QDeath within 1 hr after birth; respiratory distress;
−/R  no feeding
+/RDeath within 4 weeks after birth; growth retarda tion; poor righting reflex; poor feeding
+/QIncreased mortality; females with nurturing deficit
+/−
+/QneoNo obvious difference to wild type
+/Rneo