Table 3.

Summary of previously published SOD1 transgenic models

Transgenic lineh/m SOD1 ratioOnset of diseaseReference
h-SOD11–10No disease(Epstein et al., 1987)
(Ceballos-Picot et al., 1991)
(Gurney et al., 1994)
(Wong et al., 1995)
(Bruijn et al., 1997)
m-SOD1 nullNo SOD1No disease(Reaume et al., 1996)
h-G37R10–123.5–4 months(Wong et al., 1995)
4–56–8 months(Wong et al., 1995)
h-G85R18–10  months(Bruijn et al., 1997)
0.212–14 months(Bruijn et al., 1997)
m-G86R13–4 months(Ripps et al., 1995)
m-G86RRestricted to astocytesNo disease(Gong et al., 2000)
h-G93A44–6 months(Gurney et al., 1994)
  • h, Human SOD1; m, mouse SOD1 transgene.