Table 1.

Body composition of experimental rats

TreatmentVehicle SHU9119 SHU9119/pair-fed
Total weight450.1  ± 8.2 512.3  ± 7.7***449.5  ± 11.3
Eviscerated carcass 364.6  ± 6.7387.2  ± 5.1* 361.8  ± 9.2
Liver 15.5  ± 0.421.0  ± 0.8** 15.0  ± 0.5
Gastrointestinal tract (empty) 17.9  ± 0.8 26.9  ± 1.3*** 19.9  ± 0.7
Gastrointestinal filling 17.6  ± 1.6 37.7  ± 2.5***19.1  ± 2.1
Retroperitoneal fat 4.5  ± 0.8 11.2  ± 0.7*** 6.7  ± 0.5*
Epididymal fat 7.4  ± 0.610.9  ± 0.6*** 9.3  ± 0.7*
  • Wet weights are means ± SE expressed in grams. Rats received third cerebroventricular (i3vt) treatment for 11 d with vehicle (saline; n = 7), SHU9119 (0.5 nmol/d;n = 7), or SHU9119 (0.5 nmol/d) pair-fed with the vehicle-treated group (SHU9119/pair-fed; n = 7). *p < 0.05; **p <0.01, and ***p<0.001 denote statistical difference with the i3vt vehicle-treated group.