Table 3.

Plasma concentrations of fuel, hormones, and hepatic glycogen of experimental rats

Treatment Vehicle SHU9119SHU9119/pair-fed
Glucose, mmol/l6.67  ± 0.50 7.23  ± 0.386.18  ± 0.28
Triglycerides, mmol/l 1.57  ± 0.201.06  ± 0.16 1.30  ± 0.10
Free fatty acids, mmol/l0.25  ± 0.02 0.23  ± 0.02 0.20  ± 0.01
Cholesterol, mmol/l 1.66  ± 0.09 2.45  ± 0.10***2.18  ± 0.13**
Insulin, pmol/l 0.90  ± 0.083.21  ± 0.48*** 0.98  ± 0.16
Glucagon, ng/l93.29  ± 7.38 169.0  ± 8.78*** 97.00  ± 5.96
Corticosterone, nmol/l 103.48  ± 39.65 111.81  ± 23.51 136.10  ± 18.24
Leptin, μg/l 4.91  ± 0.6529.02  ± 2.34*** 10.03  ± 1.10**
Total hepatic glycogen, gm 1.09  ± 0.06 1.53  ± 0.14** 1.09  ± 0.09
  • Values are means ± SE. Rats received third cerebroventricular (i3vt) treatment for 11 d with vehicle (saline;n = 7), SHU9119 (0.5 nmol/d; n = 7), or SHU9119 (0.5 nmol/d) and were pair-fed with the vehicle-treated group (SHU9119/pair-fed; n = 7). **p < 0.01 and ***p < 0.001 denote statistical difference with the i3vt vehicle-treated group.