Levels of synaptic proteins in Munc13-3-deficient cerebella
| Protein level (% of wild-type control) | |
|---|---|
| Munc13-1* | 104 ± 2 |
| Munc13-2 | 94 ± 4 |
| Munc13-3 | 0 |
| α-SNAP | 81 ± 5 |
| Amphiphysin | 95 ± 10 |
| Arf6 | 105 ± 4 |
| Complexin I* | 110 ± 4 |
| Complexin II* | 107 ± 1 |
| Doc2α | 87 ± 2 |
| Dynamin | 105 ± 3 |
| GDI | 95 ± 8 |
| Mint I | 114 ± 4 |
| Msec7 | 101 ± 4 |
| Munc18-1 | 87 ± 5 |
| Neuroligin 1/3 | 105 ± 7 |
| NMDA RI | 101 ± 4 |
| NSF | 99 ± 10 |
| PSD95 | 83 ± 4 |
| Rab3A* | 108 ± 7 |
| Rabphilin | 86 ± 8 |
| SAP102 | 111 ± 5 |
| SNAP25 | 88 ± 6 |
| SV2B | 117 ± 4 |
| SV2C | 87 ± 5 |
| Synapsin I | 89 ± 5 |
| Synapsin II | 109 ± 3 |
| Synaptobrevin II | 91 ± 8 |
| Synaptogyrin* | 104 ± 5 |
| Synaptophysin | 100 ± 8 |
| Synaptoporin* | 87 ± 10 |
| Synaptotagmin I | 92 ± 5 |
| Syntaxin IA/B | 104 ± 6 |
Data are given as mean ± SEM (n = 3;
↵* n = 5). Munc13-3 levels in hetergozygous mutant cerebella were not significantly different from wild-type controls (113 ± 6; n = 3), indicating a lack of a gene dosage effect.