Table 1.

Acoustic startle reactivity levels in the DAT mutant mice

DAT (+/+)DAT (+/−)DAT (−/−)
Baseline
 Cohort 1241.2 ± 32.1203.2 ± 14.4237.6 ± 33.9
 Cohort 2, female185.0  ± 18.0186.6  ± 12.4157.8  ± 19.2
 Cohort 2, male237.6  ± 23.6302.4  ± 20.0*170.6  ± 15.8*
Raclopride
 Vehicle270.7  ± 40.2233.5  ± 17.1233.8  ± 32.3
 3.0 mg/kg263.4  ± 33.7180.7  ± 14.2218.6  ± 47.9
SCH23390
 Vehicle232.6  ± 13.8269.2  ± 15.3210.2  ± 8.7
 1.0 mg/kg223.8  ± 15.5259.2  ± 13.0199.8  ± 13.3
  • At baseline, there were no differences in startle reactivity between genotypes in Cohort 1, but the male DAT (+/−) mice in the second cohort had higher startle reactivity, and the (−/−) mice had lower startle reactivity compared with (+/+) controls (*p > 0.05). Treatment with 3.0 mg/kg raclopride or 1.0 mg/kg SCH23390 had no significant effect on the startle response in the DAT mice. Values (arbitrary units) represent mean startle magnitude ± SEM.