Table 2.

Mean (SEM) of laminar cytochrome oxidase activity units (micromoles per minute per gram of tissue wet weight) in human postmortem posterior cingulate (area 23) and primary motor cortex (area 4) in AD patients and age-matched controls

Posterior cingulate cortexPrimary motor cortex
ControlAD% DifferenceControlAD% Difference
Layer I85 (8)52 (3)2-160−39%86 (7)68 (4)−21%
Layer II88 (7)60 (3)2-160−32%103 (7)84 (4)−18%
Layer III95 (9)71 (4)*−25%115 (6)100 (4)−13%
Layer IV87 (8)66 (3)*−24%102 (5)91 (6)−11%
Layer V83 (7)63 (3)*−24%95 (6)86 (5)−9%
Layer VI73 (6)55 (3)*−25%86 (6)76 (5)−12%
Mean85 (7)61 (2)2-160−28%98 (6)84 (4)−14%
  • Significantly lower than control (

  • * p < 0.05;

  • F2-160 p < 0.01; two-tailed Bonferroni-corrected).