Table 3.

GABA EC50 values of α1β2γ2 and α1β2γ2A79C receptors before and after treatment with 2 mm MTSEA-biotin, 2 mm MTSEA-biotin-CAP, or 1 μm FLZM

ReceptorGABA EC50m) beforenTreatmentGABA EC50m) afternEC50before/EC50 after
αβγ18  ± 4.73-a3FLZM5.5  ± 0.93-16033.3
αβγA79C30  ± 123-a9FLZM7.8  ± 5.63-16033.8
αβγA79C43  ± 6.73-b3MTSEA-biotin28  ± 7.43-b,3-15031.5
αβγA79C29  ± 1.73-c3MTSEA-biotin-CAP11  ± 3.33-c,3-16032.6
  • Data represent mean ± SD values.

  • F3-150 ,

  • F3-160 Indicate values significantly different from GABA before (control), with p < 0.05 and p < 0.01, respectively.

  • F3-a EC50 values taken from Table 1.

  • F3-b EC50 values from single oocyte experiments before and after MTSEA-biotin application.

  • F3-c EC50values from single oocyte experiments before and after MTSEA-biotin-CAP application.