Table 1.

Potency of retigabine against KCNQ2/3, KCNQ1, KCNQ2, KCNQ3, and KCNQ4

Maximum shift in V1/2 (mV)Retigabine EC50m)
KCNQ2/3−30.41.9  ± 0.2 (n = 5)
KCNQ1 −0.7100.1  ± 6.5 (n = 4)1-a
KCNQ2−24.22.5  ± 0.6 (n = 5)
KCNQ3−42.80.6  ± 0.3 (n = 3)
KCNQ4−24.65.2  ± 0.9 (n = 3)
  • Columns show the maximum leftward shift ofV1/2 (see Fig. 5) induced by retigabine and the corresponding EC50 value for the shift for KCNQ2–4 (see Fig. 6), calculated as the mean ± SEM of the shifts produced in the individual experiments (number of experiments in parentheses). Note that 100 μm retigabine was sufficient to produce a maximum shift for KCNQ2/3, KCNQ2, and KCNQ3; for KCNQ4, 300 μm retigabine was required.

  • F1-a  KCNQ1, IC50 for inhibition (see Fig. 7).