Table 1.

Distension-induced release of ATP in P2X3wild-type and P2X3 knock-out mouse urinary bladder

Intravesical pressureRelease of ATP (pmol/ml)
P2X3wild-typeP2X3 knock-out
Basal pressure0.5  ± 0.1  (15)0.6  ± 0.1  (4)
7.5 mmHg4.1  ± 1.01-160  (15)3.6  ± 1.8*  (3)
15 mmHg10.7  ± 1.91-160  (11)11.6  ± 3.8*  (4)
20 mmHg20.8  ± 3.21-160  (10)21.9  ± 6.6*  (3)
25 mmHg20.9  ± 3.21-160  (4)21.9  ± 3.2*  (4)
  • * p < 0.05 and

  • F1-160 p < 0.001 versus basal release (Student'st test). In parentheses are the number of animals.