Table 1.

Additional measures of water maze performance (mean ± SEM)

MeasureControl (n = 12)Saporin (n = 7)
Swim speed averaged across training  trial blocks (cm/sec)14.46  ± 1.088.23  ± 1.86*
Thigmotaxis during training block 1 (%)73.41  ± 1.0879.41  ± 3.46
Probe trial measures
 Percentage of time in quadrant 135.65  ± 5.9531.0  ± 6.62
 Percentage of time in quadrant 233.25  ± 7.6248.59  ± 8.98
 Percentage of time in quadrant 37.71  ± 2.339.07  ± 3.43
 Percentage of time in quadrant 423.36  ± 5.2811.34  ± 5.25
Platform crossings1.33  ± 0.510.14  ± 0.14
  • For the probe trial, quadrant 4 is the target quadrant (the one which contained the platform during training trials) and quadrant 2 is the opposite quadrant from the training quadrant. No significant differences were noted in thigmotaxis (p = 0.37) or on the probe trial measures (quadrants 1–3, p > 0.22; quadrant 4, p = 0.15; platform crossings,p = 0.10). Mice showed an aversion to one of the quadrants of the swim pool, as has been noted previously in mice tested in this laboratory (Frick et al., 2000). Swim speed showed a significant lesion effect (

  • * p = 0.006), as noted in Results.