Lines of transgenic rats expressing human SOD1 with H46R or G93A mutations
| Line | Copy number | Relative SOD1 protein levels (spinal cord) (human/rat) | SOD activity relative to control (spinal cord) | Age of onset (days) | Duration (days) |
|---|---|---|---|---|---|
| H46R-2 | 2 | 1.6 | ND | None | None |
| H46R-4 | 25 | 6.0 | 0.21 | 144.7 ± 6.4 | 24.2 ± 2.9 |
| H46R-10 | 3 | 2.6 | ND | None | None |
| H46R-13 | 5 | 3.0 | 0.4 | None | None |
| H46R-17 | 2 | 0.8 | ND | None | None |
| G93A-2 | 1 | 0 | ND | None | None |
| G93A-10 | 1 | 0.8 | ND | None | None |
| G93A-24 | 3 | 0.8 | 2 | None | None |
| G93A-32 | 10 | 2.0 | ND | None | None |
| G93A-35 | 2 | ND | ND | None | None |
| G93A-37 | 2 | ND | ND | None | None |
| G93A-39 | 10 | 2.5 | 3 | 122.9 ± 14.1 | 8.3 ± 0.7 |
ND, Not determined.