Table 2.

Neuronal parameters in patched-clamped control and Bay K8644-treated CA1 neurons

DMSO (n = 9)Bay K8644
AHP amplitude at 750 msec (mV)−1.9  ± 0.4−3.6  ± 0.5* (n = 15)
Input resistance (MΩ)105.8  ± 14.991.5  ± 10.4 (n = 15)
Stimulation threshold (μA)207  ± 35.3212  ± 75.1 (n = 15)
Subthreshold 7 Hz stimulation
 FFearly (%)91.9  ± 23.198.3  ± 14.4
 FFlate (%)66.8  ± 21.055.3  ± 14.5
 FFearly, membrane potential (mV)−70.9  ± 0.2−71.1  ± 0.1 (n = 8)
 FFlate, membrane potential (mV)−70.6  ± 0.3−68.7  ± 0.5 (n = 8)
Suprathreshold 7 Hz stimulation
 FFearly, membrane potential (mV)−71.1  ± 0.5−69.7  ± 0.4 (n = 9)
 FFlate, membrane potential (mV)−67.3  ± 0.7−61.7  ± 0.92-160 (n = 9)
Suprathreshold 7 Hz stimulation + current injection
 FFearly, membrane potential (mV)N/A−71.6  ± 0.8 (n = 6)
 FFlate, membrane potential (mV)N/A−71.1  ± 0.3 (n = 6)
  • All values are mean ± SEM.

  • * p < 0.05;

  • F2-160 p < 0.001 for DMSO versus Bay K8644 effect. Values for FF or membrane potential are 2 sec averages obtained during the first 2 sec and last 2 sec periods of a 20 sec train of 7 Hz of synaptic activation. N/A, Not applicable.