Behaviors observed during microdialysis sample collection in the 10 min periods during and after BLA stimulation
Behaviors | Controls | LY354740 | LY293558 | |||
---|---|---|---|---|---|---|
During | After | During | After | During | After | |
Ambulation | 63 | 0 | 13* | 0 | 33 | |
Grooming | 0 | 59 | 0 | 25 | 0 | 11* |
Freezing | 96 | 56 | 94 | 81 | 100 | 56 |
Sniffing | 48 | 63 | 6* | 50 | 22 | 56 |
Mouth movement | 63 | 26 | 81 | 69* | 100* | 67* |
Jaw tremor | 48 | 33 | 31 | 38 | 78* | 89* |
Data are presented as percentages of animals that exhibited selected behaviors within each group. The control group (n = 27) had normal Ringer's perfused into the microdialysis probe implanted in the PFC. In the other two groups, either the mGluR2 agonist LY354740 (n = 16) or the AMPA/kainate antagonist LY293558 (n = 9) was added to the Ringer's solution that was perfused into the PFC. All animals were at rest for the 10 min period before BLA stimulation (data not shown). Asterisks denote significant differences (p < 0.05) compared with the control group.