Perifornical cell counts, sleep–wake behavior,Tb, and LMA of animals treated with vehicle or methamphetamine (0.5 mg/kg) at ZT 17 and killed 2 hr later
| Vehicle | Methamphetamine | Mann–Whitney p value | |
|---|---|---|---|
| n | 6 | 7 | |
| Fos-IR neurons | 21 ± 2 | 59 ± 3 | 0.003 |
| Orexin-IR neurons | 47 ± 5 | 52 ± 2 | N.S. |
| Double-labeled neurons | 7 ± 2 | 28 ± 2 | 0.003 |
| Non-orexin-IR, Fos-IR neurons | 14 ± 1 | 31 ± 2 | 0.003 |
| % Wake | 53.5 ± 5.4 | 100.0 ± 0.0 | 0.001 |
| % NREM sleep | 43.3 ± 4.9 | 0.0 ± 0.0 | 0.001 |
| % REM sleep | 3.3 ± 0.7 | 0.0 ± 0.0 | 0.001 |
| Tb (°C) | 37.9 ± 0.2 | 37.8 ± 0.4 | N.S. |
| Change in Tb (°C) | 0.1 ± 0.1 | 0.0 ± 0.1 | N.S. |
| LMA | 1.1 ± 0.4 | 3.0 ± 0.5 | 0.03 |