Table 1.

Effect of GLT-1 and EAAC1 knockdown on the infarct volume after transient MCAO

ICV infusionnCortex (mm3)Striatum (mm3)Total (mm3)
None6172  ± 2731  ± 5203  ± 28
aCSF5175  ± 3637  ± 7208  ± 39
GLT-1 sense5167  ± 3434  ± 9204  ± 41
GLT-1 random4164  ± 3332  ± 6199  ± 47
GLT-1 antisense8246  ± 501-a,1-b48  ± 71-a,1-b294  ± 521-a,1-b
EAAC1 sense4186  ± 4433  ± 10222  ± 47
EAAC1 random4175  ± 4936  ± 9210  ± 52
EAAC1 antisense6201  ± 4639  ± 7240  ± 50
  • Values are mean ± SD. The MCAO duration was 1 hr in all cases. Ischemic injury volumes were computed by volumetric analysis of the thionine-stained coronal sections using the NIH Image program. aCSF, Artificial CSF; ICV, intracerebroventricular.

  • F1-a p < 0.05, compared with the None or aCSF group (one-way ANOVA followed by Dunnet's multiple comparisons post test).

  • F1-b p < 0.05, compared with the respective sense or random group (ANOVA followed by Tukey-Kramer multiple comparisons post test).