Table 1.

Striatal [3H]WIN 35,428 binding densities in monkeys during the initial phase of cocaine self-administration 1-a

Brain regionsControl n = 6Cocaine 0.03 mg/kg/inj n = 4Percent difference1-bCocaine 0.3 mg/kg/inj n = 4Percent difference1-b
Rostral precommissural striatum
 Dorsolateral caudate95.1  ± 971.6  ± 5*25%79.0  ± 417%
 Dorsomedial caudate116.4  ± 999.6  ± 615%98.5  ± 615%
 Ventral caudate107.3  ± 889.5  ± 317%88.1  ± 718%
 Dorsal putamen116.1  ± 993.2  ± 720%104.7  ± 910%
 Central putamen107.2  ± 790.7  ± 715%96.9  ± 310%
 Ventral putamen85.1  ± 870.8  ± 817%77.5  ± 49%
 Accumbens56.6  ± 545.4  ± 420%47.7  ± 516%
Caudal precommissural striatum
 Dorsolateral caudate96.7  ± 772.1  ± 4*25%85.6  ± 1012%
 Dorsomedial caudate120.8  ± 6103.2  ± 615%113.6  ± 116%
 Ventral caudate88.9  ± 378.8  ± 711%82.9  ± 67%
 Dorsal putamen110.5  ± 291.4  ± 417%106.2  ± 134%
 Central putamen105.3  ± 385.5  ± 6*19%100.3  ± 15%
 Ventral putamen88.5  ± 670.9  ± 720%78.0  ± 912%
 Accumbens (shell)48.6  ± 538.4  ± 421%45.9  ± 96%
 Accumbens (core)59.4  ± 449.5  ± 317%54.1  ± 79%
 Olfactory tubercle58.3  ± 448.6  ± 617%53.4  ± 88%
  • F1-a Data represent femtomoles per milligram, wet weight tissue and are expressed as mean ± SEM.

  • F1-b Percent difference from control values.

  • * p < 0.05 different from control. Statistical analysis was performed for each brain region by means of a one-way ANOVA, followed by a post hoc LSD test comparing drug treatments to controls.

  • inj, Injection.