Table 2.

Striatal [3H]WIN 35,428 binding densities in monkeys during the chronic phase of cocaine self-administration 2-a

Brain regionsControl n = 6Cocaine 0.03 mg/kg/inj n = 4Percent difference2-bCocaine 0.3 mg/kg/inj n = 4Percent difference2-b
Rostral precommissural striatum
 Dorsolateral caudate95.1  ± 991.6  ± 84%97.7  ± 43%
 Dorsomedial caudate116.4  ± 9120.6  ± 64%124.1  ± 107%
 Ventral caudate107.3  ± 8116.2  ± 68%112.8  ± 65%
 Dorsal putamen116.1  ± 9121.4  ± 115%125.4  ± 78%
 Central putamen107.2  ± 7121.1  ± 913%116.7  ± 69%
 Ventral putamen85.1  ± 8101.8  ± 520%96.7  ± 414%
 Accumbens56.6  ± 573.4  ± 5*30%68.2  ± 220%
Caudal precommissural striatum
 Dorsolateral caudate96.7  ± 7100.6  ± 84%120.7  ± 5*25%
 Dorsomedial caudate120.8  ± 6131.8  ± 79%145.0  ± 9*20%
 Ventral caudate88.9  ± 3107.2  ± 8*21%110.6  ± 52-16025%
 Dorsal putamen110.5  ± 2120.2  ± 109%144.2  ± 92-16531%
 Central putamen105.3  ± 3125.6  ± 1119%134.5  ± 8*28%
 Ventral putamen88.5  ± 6111.2  ± 8*26%114.2  ± 9*29%
 Accumbens (shell)48.6  ± 563.7  ± 3*31%74.7  ± 52-16554%
 Accumbens (core)59.4  ± 481.1  ± 72-16037%86.7  ± 62-16546%
 Olfactory tubercle58.3  ± 482.6  ± 12-16042%80.4  ± 12-16538%
  • F2-a Data represent femtomoles per milligram, wet weight tissue and are expressed as mean ± SEM.

  • F2-b Percent difference from control values.

  • * p < 0.05;

  • F2-160 p < 0.01;

  • F2-165 p < 0.005 different from control. Statistical analysis was performed for each brain region by means of a one-way ANOVA, followed by a post hoc LSD test comparing drug treatments to controls.

  • inj, Injection.