Striatal [3H]WIN 35,428 binding densities in monkeys during the long-term phase of cocaine self-administration 3-a
| Brain regions | Control n = 3 | Cocaine 0.03 mg/kg/inj n = 3 | Percent difference3-b |
|---|---|---|---|
| Rostral precommissural striatum | |||
| Dorsolateral caudate | 86.7 ± 12 | 102.6 ± 12 | 18% |
| Dorsomedial caudate | 102.2 ± 4 | 124.9 ± 12 | 22% |
| Ventral caudate | 90.0 ± 10 | 116.8 ± 7 | 30% |
| Dorsal putamen | 110.9 ± 13 | 135.2 ± 16 | 22% |
| Central putamen | 98.8 ± 13 | 131.4 ± 10 | 33% |
| Ventral putamen | 85.4 ± 8 | 103.8 ± 5 | 21% |
| Accumbens | 54.5 ± 1 | 63.3 ± 8 | 16% |
| Caudal precommissural striatum | |||
| Dorsolateral caudate | 108.0 ± 19 | 110.7 ± 8 | 2% |
| Dorsomedial caudate | 125.0 ± 16 | 144.2 ± 13 | 15% |
| Ventral caudate | 86.0 ± 6 | 124.1 ± 13-165 | 44% |
| Dorsal putamen | 114.3 ± 16 | 140.9 ± 12 | 23% |
| Central putamen | 101.4 ± 17 | 131.9 ± 5 | 30% |
| Ventral putamen | 83.9 ± 11 | 108.9 ± 4 | 30% |
| Accumbens (shell) | 51.9 ± 1 | 59.7 ± 33-150 | 15% |
| Accumbens (core) | 59.7 ± 4 | 83.2 ± 33-160 | 39% |
| Olfactory tubercle | 55.4 ± 4 | 73.4 ± 23-160 | 33% |
↵F3-a Data represent femtomoles per milligram, wet weight tissue and are expressed as mean ± SEM.
↵F3-b Percent difference from control values.
↵F3-150 p < 0.05;
↵F3-160 p < 0.01;
↵F3-165 p < 0.005 different from control. Statistical analysis was performed for each brain region using Student's t test to compare drug treatments with controls.
inj, Injection.