Table 1.

Tissue content of dopamine, noradrenaline (NA), serotonin, and metabolites in the striatum and frontal cortex of wild-type and Grin1D481N/K483Q mice

Tissue content (ng/gm)StriatumFrontal cortex
Wild typeD481N/K483QWild typeD481N/K483Q
Dopamine13279  ± 43116981  ± 6341-16056  ± 1244  ± 5
DOPAC1361  ± 231651  ± 451-16023  ± 225  ± 2
HVA1453  ± 451565  ± 16049  ± 448  ± 6.4
NA124  ± 11210  ± 62200  ± 6230  ± 12
Serotonin1139  ± 291390  ± 64*411  ± 18456  ± 23
5-HIAA522  ± 16617  ± 29*91  ± 494  ± 11
  • Data are presented as mean ± SE for wild-type (n = 11) and Grin1D481N/K483Q (n = 5) mice;

  • * p < 0.05;

  • F1-160 p < 0.005; two-tailed t test.