Table 2.

Neurological assessment of wild-type andGrin1D481N/K483Q mice

Neurological assessmentWild typeD481N/K483Q
Body weight (gm)27.6  ± 1.021.6  ± 0.52-160
Body temperature (°C)37.3  ± 0.237.5  ± 0.2
Flexion reflex14/1414/14
Grip strength (g)154.3  ± 6.264.9  ± 6.92-165
Horizontal wire test (sec) 57 (29–60)1.5 (0–8)2-165
Rotarod-16 rpm (sec)120 (62–120) 9 (5–18)2-165
Rotarod-32 rpm (sec) 48 (19–88) 8 (3–12)2-165
  • Data are presented as mean ± SE; median with interquartile range in parentheses (Mann–Whitney U test); proportion of group, n = 14/group.

  • F2-160 p < 0.01;

  • F2-165 p < 0.001; two-tailed ttest.