Last 3 d of training | First day extinction | Last day extinction | ||||||
---|---|---|---|---|---|---|---|---|
Alcohol intake (gm/kg) | Alcohol reinforcements | Active lever responses | Inactive lever responses | Active lever responses | Inactive lever responses | Active lever responses | Inactive lever responses | |
Exp 1 | ||||||||
DRN (8-OH-DPAT) | 0.9 ± 0.07 | 18.9 ± 1.5 | 68.9 ± 6.4 | 6.5 ± 0.9 | 55.4 ± 9.2 | 7.2 ± 1.5 | 9.5 ± 1.6 | 2.3 ± 0.9 |
MRN (8-OH-DPAT) | 1.1 ± 0.08 | 24.5 ± 1.7 | 99.9 ± 6.6 | 4.9 ± 0.9 | 68.4 ± 9.8 | 3.1 ± 1.8 | 9.4 ± 1.2 | 2.5 ± 1.1 |
Exp 2 | ||||||||
ICV CRF | 0.94 ± 0.04 | 18.6 ± 0.9 | 70.3 ± 3.5 | 4.5 ± 0.6 | 77.4 ± 7.1 | 9.4 ± 2.2 | 7.1 ± 0.9 | 1.5 ± 0.4 |
MRN CRF | 1.04 ± 0.06 | 23.8 ± 1.4 | 89.6 ± 5.6 | 3.3 ± 0.6 | 54.7 ± 8.1 | 4.7 ± 16 | 9.1 ± 1.4 | 4.0 ± 1.0 |
MRN d-Phe CRF | 0.77 ± 0.05 | 18.4 ± 1.2 | 79.9 ± 6.9 | 4.4 ± 1.2 | 52.3 ± 8.4 | 2.2 ± 0.8 | 11.4 ± 1.8 | 1.3 ± 0.6 |
Last 3 d of training, Mean ± SEM alcohol intake, alcohol reinforcements, and total responses on the active (reinforcements plus timeout responses) and the inactive levers. Day 1 extinction, Mean non-reinforced responses on the active and inactive levers on the first day of extinction. Last day extinction, Mean non-reinforced responses on the active and inactive levers on the last day of extinction before the start of the tests for reinstatement. Exp, Experiment; ICV, intracerebroventricular.