Table 1.

Neuronal firing rates and correlation in the pallidum

NormalMPTP1-aDRT-off1-bDRT-on1-c
A. Firing rates (spikes/sec),GPe57.1 ± 2.1 (n = 96)45.4 ± 1.7 (n = 92)*30.3 ± 1.9 (n = 89)*80.3 ± 3.8 (n = 51)*,**
 mean ± SEM1-dGPi62.9 ± 3.3 (n = 22)75.3 ± 4.5 (n = 37)69.5 ± 5.9 (n = 17)29.1 ± 4.7 (n = 30)*,**
B. Percentage of correlated GPall-GPall1-f16.7% (100/599)46.9% (399/851)*71.4% (359/503)*25.0% (94/376)**
 neuronal pairs1-eGPe-GPe26.3% (26/99)41.9% (26/62)78.8% (93/118)*32.6% (14/43)**
GPi-GPi20.0% (9/45)82.1% (55/67)*80.0% (8/10)*57.1% (12/21)
C. Percentage of oscillatory outGPall-GPall1-f4.0% (4/100)67.7% (270/399)*43.7% (157/359)*42.6% (40/94)*
 of all non-flat correlograms1-eGPe-GPe15.4% (4/26)38.5% (10/26)45.2% (42/93)35.7% (5/14)
GPi-GPi0% (0/9)94.5% (52/55)*87.5% (7/8)*83.3% (10/12)*
  • F1-a  MPTP corresponds to MPTP-treatedl-DOPA-naive parkinsonian monkey.

  • F1-b  DRT-off corresponds to off periods (before morning dose) of MPTP monkey undergoing daily DRT.

  • F1-c  DRT-on corresponds to on periods of MPTP monkey after DRT.

  • F1-d  Comparisons were done using Student'st test. All states were compared with the normal state (*p < 0.001). DRT-on was compared with DRT-off as well (**p < 0.001).

  • F1-e  Comparisons were done using χ2 test. All states were compared with the normal state (*p < 0.001). DRT-on was compared with DRT-off as well (**p < 0.001).

  • F1-f  GPall-GPall—all combinations of GPe, GPi, and GP neuronal pairs.