BALB/cWah1 | 9XCA/Wah | p | ||
---|---|---|---|---|
Training (day 1) | Before CS | 3 ± 1 (n = 12) | 5 ± 1 (n = 12) | NS |
After US | 19 ± 4 (n = 12) | 30 ± 7 (n = 12) | NS | |
Testing (day 2) | Contextual | 46 ± 6 (n = 12) | 46 ± 6 (n = 12) | NS |
Acclimation | 2 ± 1 (n = 12) | 8 ± 2 (n = 12) | <0.01 | |
Cued | 34 ± 7 (n = 12) | 35 ± 6 (n = 12) | NS | |
Contextual extinction | Day 3 | 27 ± 3 (n = 7) | 53 ± 4 (n = 7) | <0.001 |
Day 5 | 20 ± 5 (n = 7) | 32 ± 5 (n = 7) | <0.05 | |
Day 7 | 10 ± 3 (n = 7) | 18 ± 6 (n = 7) | NS | |
Day 9 | 6 ± 1 (n = 7) | 16 ± 4 (n = 7) | <0.02 | |
Cued extinction (day 2) | Acclimation | 4 ± 2 (n = 12) | 20 ± 5 (n = 8) | <0.01 |
Trial block 1 | 22 ± 3 (n = 12) | 23 ± 3 (n = 8) | NS | |
Trial block 2 | 24 ± 3 (n = 12) | 17 ± 3 (n = 8) | NS | |
Trial block 3 | 22 ± 3 (n = 12) | 18 ± 3 (n = 8) | NS | |
Trial block 4 | 18 ± 3 (n = 12) | 16 ± 3 (n = 8) | NS | |
Trial block 5 | 19 ± 3 (n = 12) | 15 ± 4 (n = 8) | NS | |
Trial block 6 | 20 ± 4 (n = 12) | 21 ± 5 (n = 8) | NS |
Values reported are mean ± SEM percentage of freezing followed by n mice tested. For explanation of intervals tested, see Materials and Methods. A separate group of mice was used for cued extinction testing. p values were derived from Student'st test, and significance was considered p < 0.05. NS, Not significantly different.