Table 1.

Relative densitometry values for DARPP-32 and DAT in amphetamine- and cocaine-treated P24, P33, and adult mice relative to control, saline values, arbitrarily set at 100%

AmphetamineCocaine
P24P33AdultP24P33Adult
DARPP-32
 NA94.7  ± 23.4 (7)87.5  ± 13.0 (10)99.9  ± 5.4 (6)92.9  ± 11.3 (7)93.5  ± 10.4 (8)81.2  ± 24.4 (4)
 CPu95.0  ± 3.8 (12)97.9  ± 7.9 (12)106.9  ± 9.5 (10)95.5  ± 6.4 (12)98.9  ± 6.8 (8)105.9  ± 9.7 (11)
DAT
 NA125.2  ± 37.3 (6)106.2  ± 27.4 (5)84.6  ± 23.9 (7)83.6  ± 9.9 (12)104.6  ± 11.9 (11)94.4  ± 11.3 (5)
 CPu82.9  ± 12.8 (12)102.5  ± 16.8 (12)69.2  ± 24.4 (8)102.8  ± 25.3 (12)114.3  ± 34.1 (8)123.8  ± 19.3 (11)
  • Changes in DARPP-32 and DAT immunoreactivity after amphetamine and cocaine administration in post-weanling (P24), periadolescent (P33), and adult (P60) mice. Values shown represent percentage of control values determined for animals of the same age injected with saline. Numbers of animals in the amphetamine and cocaine groups are given in parentheses, and n values for saline-injected animals were similar in each case. p > 0.05 in all cases. NA, Nucleus accumbens; CPu, caudate putamen.