Table 2.

B_max (fmol/mg protein) andK_D (nm) values of [leucyl-³H]-N/OFQ binding to NOP receptors in membranes prepared from hippocampi and thalami taken from control and kainate-treated rats

	Hippocampus		Thalamus
	B_max	K_D	B_max	K_D
Control	264.6 ± 26.7	0.61 ± 0.26	139.0 ± 9.6	0.47 ± 0.13
Kainate^2-a	97.2 ± 9.3^2-160	0.57 ± 0.21	91.2 ± 9.2^*	0.34 ± 0.14

↵* p < 0.05,
↵F2-160 p < 0.01 versus the corresponding region in controls; two-tailed t test.
↵F2-a Kainate-treated animals were killed 3 d after administration of the convulsant agent. Data are the mean ± SE of four to six animals per group, each run in quadruplicate.