Table 1.

Physiological and mortality measurements associated with transient cerebral ischemia in wild-type and CB1 mutant mice

CB1 receptor genotype
+/++/−−/−
Arterial blood pH
 Pre-ischemic7.31  ± 0.047.31  ± 0.027.35  ± 0.02
 Intra-ischemic7.38  ± 0.037.34  ± 0.047.38  ± 0.02
 Post-ischemic7.37  ± 0.027.34  ± 0.057.36  ± 0.03
Arterial blood po2 (mm Hg)
 Pre-ischemic151  ± 14158  ± 17164  ± 19
 Intra-ischemic165  ± 22163  ± 22175  ± 18
 Post-ischemic188  ± 7159  ± 16174  ± 15
Arterial blood pco2 (mm Hg)
 Pre-ischemic39  ± 537  ± 536  ± 3
 Intra-ischemic35  ± 237  ± 533  ± 4
 Post-ischemic37  ± 240  ± 637  ± 4
Rectal temperature (°C)
 Pre-ischemic36.8  ± 0.237.3  ± 0.137.2  ± 0.1
 Intra-ischemic37.2  ± 0.336.6  ± 0.237.4  ± 0.4
 Post-ischemic36.9  ± 0.236.8  ± 0.337.0  ± 0.4
Mortality2/14 (14%)2/11 (18%)5/16 (31%)
  • Physiological measurements were made immediately before (pre-ischemic), 10 min after the onset of (intra-ischemic), or 10 min after termination of (post-ischemic) 20 min of MCA occlusion followed by reperfusion. Mortality was measured at 24 hr. Data are means ± SEM (n = 5).