Table 1.

Comparison of mIPSCav attributes in morphologically identified neurons of seizure-resistant, normal, and seizure-prone rat strains

Strain, cell type
Seizure-resistantNormalSeizure-prone
PyramidalNonpyramidalPyramidalNonpyramidalPyramidalNonpyramidal
Number of cells1512159151241-b
τ1(msec)1.7  ± 0.13*1.6  ± 0.12.4  ± 0.22.1  ± 0.23.0  ± 0.7*5.1  ± 0.51-165
τ2 (msec)20.3  ± 1.01-16521.0  ± 0.824.2  ± 2.524.3  ± 2.427.7  ± 3.4*39.9  ± 5.21-16526.6  ± 6.7
% τ11-a40.0  ± 5.130.0  ± 2.940.0  ± 2.530.0  ± 6.740.0  ± 2.546.7  ± 4.5
Amplitude (pA)−57.3  ± 4.01-165−59.8, 3.6*−44.6  ± 3.7−51.7  ± 5.2−39.7, 3.8−34.0  ± 4.1*−29.4

  • Values are mean ± SEM.

  • ↵F1-a  Percentage of deactivation time course devoted to fastest time constant.

  • ↵F1-b  Neurons identified as having monoexponentially decaying mIPSCavs.

  • Significance with respect to neurons of the same morphology in normal rats:

  • ↵* p < 0.05;

  • F1-160 p < 0.01;

  • ↵F1-165 p< 0.001.