Table 1.

Nitrotyrosine levels (pg/μg protein)

SalineMinocyclineMPTPMPTP–minocycline
Ventral midbrain16.2  ± 1.318.5  ± 1.732.2  ± 6.0*21.8  ± 1.81-160
Cerebellum13.1  ± 0.814.0  ± 2.113.4  ± 1.011.7  ± 1.1
  • Nitrotyrosine levels are significantly different among groups in the ventral midbrain (F(3,23) = 4.56;p < 0.05) but not in cerebellum (F(3,23) = 0.618; p > 0.05).

  • * p < 0.05, more than saline-injected and minocycline-injected control mice.

  • F1-160 p < 0.05, less than MPTP-injected mice but not different from both control groups. Saline, Mice injected with saline; Minocycline, mice injected with minocycline only (45 mg/kg twice daily); MPTP, mice injected with MPTP only (18 mg/kg MPTP for 4 injections in one day); MPTP–minocycline, mice injected with both MPTP and minocycline. Values are means ± SEM (n = 6–8 per group).