Saline | Minocycline | MPTP | MPTP–minocycline | |
---|---|---|---|---|
Ventral midbrain | 16.2 ± 1.3 | 18.5 ± 1.7 | 32.2 ± 6.0* | 21.8 ± 1.81-160 |
Cerebellum | 13.1 ± 0.8 | 14.0 ± 2.1 | 13.4 ± 1.0 | 11.7 ± 1.1 |
Nitrotyrosine levels are significantly different among groups in the ventral midbrain (F(3,23) = 4.56;p < 0.05) but not in cerebellum (F(3,23) = 0.618; p > 0.05).
↵* p < 0.05, more than saline-injected and minocycline-injected control mice.
↵F1-160 p < 0.05, less than MPTP-injected mice but not different from both control groups. Saline, Mice injected with saline; Minocycline, mice injected with minocycline only (45 mg/kg twice daily); MPTP, mice injected with MPTP only (18 mg/kg MPTP for 4 injections in one day); MPTP–minocycline, mice injected with both MPTP and minocycline. Values are means ± SEM (n = 6–8 per group).