Table 2.

Displacement of [3H]flunitrazepam in vitro 2-a

CompoundIC50 nm
3-PBC11  ± 0.80
3-EBC24  ± 2.1
Diazepam6  ± 0.62
βCCE5  ± 0.20
  • F2-a Displacement potencies of several three-substituted β-carbolines and diazepam at wild-type BDZ receptors using cerebral cortical membranes. Values are the means ± SEM of three or more experiments. See Cox et al. (1998) for methodological details.