Table 2.

Brain Aβ40 and Aβ42 in TBS and formic acid extracts after intracerebroventricular infusion of GM1 or vehicle

nAβ40      Aβ42
Picomoles of Aβ per gram of tissue
TBS-soluble Aβ
 Vehicle infusion71.1  ± 0.10.7  ± 0.1
 GM1 infusion45.8  ± 1.62.1  ± 0.2
(p  = 0.04)(p  = 0.001)
FA-soluble Aβ
 Vehicle infusion7179  ± 43210  ± 37
 GM1 infusion4212  ± 26231  ± 15
(p  = 0.29)(p  = 0.98)
  • Aβ was extracted by the four-step method (Kawarabayashi et al., 2001). Data are presented as mean ± SEM.