Absolute values of DAT and SERT binding in core, medial shell, ventral shell, ventral caudate-putamen (ventral CP), and olfactory tubercle (OT) in experiment 2
| Morphine | Amphetamine | |||
|---|---|---|---|---|
| Shell (vehicle) | Shell (6-OHDA) | Shell (vehicle) | Shell (6-OHDA) | |
| Experiment 2 | ||||
| n | 10 | 12 | 10 | 12 |
| DAT | ||||
| Core | 755±22 | 715±20 | 760±25 | 674±20 |
| Medial shell | 473±17 | 166±21 | 407±53 | 157±17 |
| Ventral shell | 429±12 | 382±14 | 437±21 | 364±15 |
| Ventral CP | 535±18 | 525±9 | 517±21 | 501±16 |
| OT | 670±18 | 612±32 | 695±43 | 618±34 |
| SERT | ||||
| Core | 414±14 | 408±14 | 385±9 | 382±15 |
| Medial shell | 517±14 | 530±19 | 510±12 | 501±23 |
| Ventral shell | 481±43 | 534±50 | 533±55 | 474±41 |
| Ventral CP | 327±31 | 343±29 | 354±40 | 322±26 |
| OT | 737±24 | 688±18 | 672±19 | 672±24 |
Values are mean ± SEM[125I]RTI-55 binding to DAT or SERT (expressed as attomol per milligram of tissue), obtained at a subsaturating concentration of radioligand.