Vigilance state parameters recorded from Cav2.2−/− mice and Cav2.2+/+ wild-type littermates
| REM sleep | NREM sleep | Awake | ||||
|---|---|---|---|---|---|---|
| +/+ | −/− | +/+ | −/− | +/+ | −/− | |
| Total time (minutes) | 47±3.5 | 51.3±2 | 440±9 | 441±10 | 232±13 | 226±11 |
| Episode duration (seconds) | 69.3±4 | 113±4** | 289±14 | 333±24 | 168±13 | 177±19 |
| Number of episodes | 41.5±4.1 | 27.3±0.7** | 92.3±4.4 | 82.2±7.9 | 84.3±4.6 | 80.4±7.7 |
| Average occurrence (minutes) | 26.1±2.2 | 29.6±1.1 | 12.6±0.7 | 16.6±0.6** | 22.2±1.3 | 26.9±1.3* |
| REM latency (minutes) | 9±0.1 | 11.3±0.8* | ||||
| Inter-REM interval (minutes) | 16.4±1.8 | 24±0.7** | ||||
| Total time (minutes) | 14.9±2 | 11.6±2.2 | 253±31 | 218±35 | 451±32 | 489±37 |
| Episode duration (seconds) | 56.7±5.9 | 54±5.6 | 279±17 | 298±29 | 574±114 | 839±249 |
| Number of episodes | 15.9±1.9 | 14.1±3.3 | 53.9±5.6 | 44.7±7.2 | 52.3±5.6 | 44.7±7.2 |
| Average occurrence (minutes) | 83.6±13.2 | 109.6±30 | 23.4±3.1 | 31.6±9.9 | 30.7±6.2 | 39.1±13.1 |
| REM latency (minutes) | 9.4±0.4 | 10.4±0.8 | ||||
| Inter-REM interval (minutes) | 45.8±4.3 | 63.7±15.3 | ||||
Data (mean ± SEM) are itemized separately for light phase (white) and dark phase (gray). Asterisks indicate differences between (+/+) (n=8) and (−/−) (n=8) mice (*p < 0.05;**p < 0.01).