Table 1.

Regions activated for successful inhibitions (STOPS) and failed inhibitions (ERRORS)

Center of mass
Structure Brodmann area Hemisphere Volume (μl) xyz
Successful inhibitions (STOPS)
Frontal lobe
Middle frontal gyrus 9 R 667 44 −21 28
6 R 259 35 1 50
Inferior frontal gyrus 9 R 539 51 −5 20
Superior frontal gyrus 6 R 2739 3 −5 52
Precentral gyrus 6 R 336 39 4 42
Cingulate gyrus 24 L 359 −6 −26 22
24/32 R 123 12 −3 44
6/32* R 663 9 −28 32
Parietal lobe
Inferior parietal lobule 7/40 R 132 33 56 40
40 R 1018 49 38 42
Temporal lobe
Middle temporal gyrus 21 R 141 57 44 −2
Subcortical
Putamen L 3587 −23 −2 6
- R 3277 26 −9 4
Thalamus R 448 7 14 5
Insula 47** R 149 47 −12 −4
Failed inhibitions (ERRORS)
Frontal lobe
Middle frontal gyrus 6 R 644 19 2 60
6 R 125 24 −8 50
Medial frontal gyrus 6** R 386 5 −7 60
Superior frontal gyrus 6 L 108 −4 9 56
Precentral gyrus 6 R 150 42 −6 39
Inferior frontal gyrus 6** L 522 −45 2 31
Cingulate gyrus 24** R 289 4 14 31
Cingulate/medial frontal gyrus/superior frontal gyrus 6/8/32* R 3650 4 12 46
Parietal lobe
Inferior parietal lobule 40 R 280 51 −39 40
40 R 186 43 −48 39
Temporal lobe
Middle temporal 39/40 R 108 47 −45 27
Gyrus 37 L 130 −50 −57 5
Subcortical
Putamen R 3194 25 8 4
Thalamus L 117 −11 −18 11
Insula 13** L 1080 −30 13 6
  • Positive center-of-mass coordinates for x, y, and z refer to locations right (x), posterior (y), and superior (z) to the anterior commissure. Brain regions in which between-group comparisons revealed significant differences in activation between cocaine users and controls are denoted: *p ≤ 0.05; **p ≤ 0.01. R, Right; L, left.