Lack of effect of capsaicin and NMDA on MOR internalization
| Drugs | Drug concentration | Incubation with drug | Incubation without drug | %MOR neurons with internalization | n |
|---|---|---|---|---|---|
| None | 20 min | 11 ± 1 | 10 | ||
| Capsaicin | 10 μm | 20 min | 0 min | 12 ± 3 | 4 |
| NMDA, D-Ser | 100 μm, 10 μm | 1 min | 10 min | 8 ± 2 | 4 |
Coronal spinal cord slices were incubated at 35°C in aCSF containing peptidase inhibitors (amastatin, captopril, and phosphoramidon) and the drugs indicated. Data are the mean ± SE of n slices. ANOVA indicated no significant differences from “None” (p = 0.35).